Interferon regulatory factor 7-mediated responses are defective in cord blood plasmacytoid dendritic cells
نویسندگان
چکیده
منابع مشابه
Interferon regulatory factor 7-mediated responses are defective in cord blood plasmacytoid dendritic cells.
Plasmacytoid dendritic cells (pDC) are specialized in massive production of type I interferons (IFN) upon viral infections. Activation of IFN regulatory factor (IRF)-7 is critically required for the synthesis of type I IFN in pDC. IRF-7 is highly expressed by resting pDC and translocates into the nucleus to initiate type I IFN transcription. In a previous work, we observed an impaired IFN-alpha...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2008
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200737760